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The Region of Ponte, 'the Bridge,' takes its name from the ancient Triumphal Bridge which led from the city to the Vatican Fields, and at low water some fragments of the original piers may be seen in the river at the bend just below Ponte Sant' Angelo, between the Church of Saint John of the Florentines on the one bank, and the Hospital of Santo Spirito on the other. In the Middle Age, according to Baracconi and others, the broken arches still extended into the stream, and upon them was built a small fortress, the outpost of the Orsini on that side. The device, however, appears to represent a portion of the later Bridge of Sant' Angelo, built upon the foundations of the AElian Bridge of Hadrian, which connected his tomb with the Campus Martius.
The Region consists of the northwest point of the city, bounded by the Tiber, from Monte Brianzo round the bend, and down stream to the new Lungara bridge, and on the land side by a very irregular line running across the Corso Vittorio Emanuele, close to the Chiesa Nuova, and then eastward and northward in a zigzag, so as to take in most of the fortresses of the Orsini family, Monte Giordano, Tor Millina, Tor Sanguigna, and the now demolished Torre di Nona. The Sixth and Seventh Regions adjacent to the Fifth and to each other would have to be included in order to take in all that part of Rome once held by the only family that rivalled, and sometimes surpassed, the Colonna in power.