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Empedocles says, that the fleshy parts of us are constituted by the contemperation of the four elements in us; earth and fire mixed with a double proportion of water make the nerves; but when it happens that the nerves are refrigerated where they meet the air, then the nails are made; the bones are produced by two parts of water and the same of air, with four parts of fire and the same of earth, duly mixed together; sweat and tears flow from the liquefaction of these bodies of ours.