In the Palace of the King by F. Marion Crawford

Dolores and Ruy Gomez had passed through the outer vestibule, and he left her to pursue his way towards the western end of the Alcazar, which was at a considerable distance from the royal apartments. Dolores went down the corridor till she came to the niche and the picture before which Don John had paused to read the Princess of Eboli's letter after supper. She stopped a moment, for she suddenly felt that her strength was exhausted and that she must rest or break down altogether. She leaned her weight against the elaborately carved railing that shut off the niche like a shrine, and looked at the painting, which was one of Raphael's smaller masterpieces, a Holy Family so smoothly and delicately painted that it jarred upon her at that moment as something untrue and out of all keeping with possibility.

Though most perfectly drawn and coloured, the spotlessly neat figures with their airs of complacent satisfaction seemed horribly out of place in the world of suffering she was condemned to dwell in, and she fancied, somewhat irreverently and resentfully, that they would look as much out of keeping with their surroundings in a heaven that must be won by the endurance of pain. Their complacent smiles seemed meant for her anguish, and she turned from the picture in displeasure, and went on.