Arrowsmith by Sinclair Lewis

Midmost of the black-soiled Iowa plain, watered only by a shallow and insignificant creek, the city of Nautilus bakes and rattles and glistens. For hundreds of miles the tall corn springs in a jungle of undeviating rows, and the stranger who sweatily trudges the corn-walled roads is lost and nervous with the sense of merciless growth.

Nautilus is to Zenith what Zenith is to Chicago.