Arrowsmith by Sinclair Lewis

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They wanted to study further the exact mechanism of the action of their quinine derivatives. This was difficult with the mice which Terry had contrived to use instead of monkeys, because of their size. Martin had brought with him strains of Bacillus lepisepticus, which causes a pleuro-pneumonia in rabbits, and their first labor was to discover whether their original compound was effective against this bacillus as well as against pneumococcus. Profanely they found that it was not; profanely and patiently they trudged into an infinitely complicated search for a compound that should be.

They earned their living by preparing sera which rather grudgingly they sold to physicians of whose honesty they were certain, abruptly refusing the popular drug-vendors. They thus received surprisingly large sums, and among all clever people it was believed that they were too coyly shrewd to be sincere.

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