Arrowsmith by Sinclair Lewis

His Junior year was a whirlwind. To attend lectures on physical diagnosis, surgery, neurology, obstetrics, and gynecology in the morning, with hospital demonstrations in the afternoon; to supervise the making of media and the sterilization of glassware for Gottlieb; to instruct a new class in the use of the microscope and filter and autoclave; to read a page now and then of scientific German or French; to see Madeline constantly; to get through it all he drove himself to hysterical hurrying, and in the dizziest of it he began his first original research-his first lyric, his first ascent of unexplored mountains.

He had immunized rabbits to typhoid, and he believed that if he mixed serum taken from these immune animals with typhoid germs, the germs would die. Unfortunately-he felt-the germs grew joyfully. He was troubled; he was sure that his technique had been clumsy; he performed his experiment over and over, working till midnight, waking at dawn to ponder on his notes. (Though in letters to Madeline his writing was an inconsistent scrawl, in his laboratory notes it was precise.) When he was quite sure that Nature was persisting in doing something she ought not to, he went guiltily to Gottlieb, protesting, "The darn bugs ought to die in this immune serum, but they don't. There's something wrong with the theories."